Here we describe an alternative approach, based on the combination of ion mobility–mass spectrometry (IM-MS) and quantum chemistry (QM), for the direct enantiomers differentiation in crude essential oils. Tetrodotoxin (TTX, 1), a potent neurotoxin, has been found in various animal species in both marine and terrestrial environments. In this review, we present fundamental information concerning the biology of these three virus families, including their genomic makeup, mode of infection of human cells, and key proteins that may offer targeted therapies. (strain ZO-R1-1), isolated from roots of the medicinal plant Zingiber officinale, yielded nine new indole diterpenoids (1–9), together with 13 known congeners (10–22). Authors must apply for GPI funding at … The structures for pandangolides 2 and 4 should also be considered for revisions. Article Processing Charge is applicable and Authors are required to pay only after acceptance of the manuscript for publishing. Finally, inhaled ascaridole and p-cymene had no negative effect on motor coordination, as observed during the Rota-rod test. The following review will focus on the pharmacological developments of the next generation of phytocannabinoid therapeutics. Therefore, via activation of the GABAergic system, ascaridole and p-cymene mediate the sleep-promoting effect of DAEO. In order to improve their efficacy, a series of new hydroxamic-acid-containing β-carbolines connected via a hydroxycinnamic acid moitey (12a–f) were developed to incorporate histone deacetylase (HDAC) inhibition for possible synergistic effects. The structures of these compounds were determined by extensive analysis of 1D and 2D NMR spectroscopic data. Genome sequencing of strain S-4 revealed the presence of a biosynthetic gene cluster (BGC) encoding glycosylated type I polyketides (PKS). The essential oil obtained from Dysphania ambrosioides leaves (DAEO) has antifungal, antioxidant, and antimicrobial properties. The Journal of Experimental and Clinical Anatomy is another chance for your the free journal publication! The X-ray crystallographic data of 1 and 3 permitted definition of their absolute configurations. Moreover, corchorusoside C induced DU-145 cell shrinkage and cell detachment. To obtain insight into DAEO’s effects on the central nervous system (CNS), ascaridole and p-cymene were evaluated for sedative activity by using the caffeine-treated excitatory mouse model. Electronic circular dichroism spectra were used to determine the absolute configuration. The proposed sulfur side chain at C-3 in pandangolide 3 (5) was revised to be at C-2 by detailed analysis of the NMR data and by a comparison with data for thiocladospolide A (1). NOTE: ONE THING SHOULD BE NOTED THAT THIS JOURNAL (JOURNAL OF NATURAL PRODUCTS)- ISSN 0974 – 5211; is a new, free assess, only ON-LINE, ANNUAL science journal published from INDIA and THIS IS NOT RELATED OR RESEMBLED IN ANY WAY WITH ALREADY PUBLISHING monthly JOURNAL ‘JOURNAL OF NATURAL PRODUCTS’ ISSN 0163-3864 BY ‘AMERICAN CHEMICAL SOCITY’ OR WITH ANY OTHER science journals. This website uses cookies to improve your user experience. One protective measure that had been proposed is employing small-molecule therapeutics capable of mitigating the toxicity of AfB1; however, to date, these efforts have had little clinical success. Journals can be searched using free text and filtered by category, language and presence on other databases. The absolute configuration of 1 was validated by obtaining (+)-osbeckic acid through acid hydrolysis. Compounds 1 and 2 possess a benzo[b]fluorene aglycon modified by C-glycosylation with l-amicetose. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1–10. The noursamycins A–F are chlorinated cyclic hexapeptides, which were identified and isolated from the strain Streptomyces noursei NTR-SR4 overexpressing a LuxR-like transcriptional activator. Compounds 1–5 showed significant, noncytotoxic inhibition of T lymphocyte proliferation, with IC50 values between 1.0 and 3.7 μM. Compounds 1–8 showed significant transcriptional activation of liver X receptor α with EC50 values of 1.7–50 μM, and 7 and 8 were the most potent agonists. In the biological assays, venturicidin A (4) and E (2) displayed a high selective cytotoxicity against acute monocytic leukemia MV-4-11 cells with IC50 values of 0.09 and 0.94 μM, respectively. To clarify the absolute configuration of an unusual amino acid moiety, we synthesized two possible diastereomers of hoshinoamide C and determined its absolute configuration based on a comparison of their spectroscopic data with those of the natural compound. A scientific open access journal in the field of natural products. Analysis of 13C NMR spectroscopic data of the phlegmarine subset of Lycopodium alkaloids revealed spectral patterns that allowed the stereochemical arrangement of the four stereogenic carbons in the decahydroquinoline core to be established. The mu opioid receptor agonists were further evaluated for analgesic properties but demonstrated limited efficacy in assays of thermal nociception. Compounds 1, 3, and 5 are the first representatives of resin glycosides with 11S-hydroxyheptadecanoic acid as the aglycone. Journal of Natural Remedies publishes original articles related to utilisation of any natural source for remedy including bioactive natural products. These included the DPPH assay, inhibition of lipid peroxidation products accumulation, inhibition of H2O2-induced hemolysis, and oxidation of oxyhemoglobin. DOI: 10.1021/acs.jnatprod.0c00966 [ASAP] … Despite their low free-radical-scavenging capacity, allylpolyalkoxybenzenes can contribute to the total antioxidant potencies of plant essential oils. A chemical investigation of the endophyte Penicillium sp. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry. Compound 1 showed radical scavenging activity in DPPH and superoxide quenching assays, and 3 and 4 displayed antimicrobial activity against Gram-positive bacteria. Asperunguisin C (3) showed cytotoxicity against the human cancer cell line A549 with an IC50 value of 6.2 μM. Please reconnect, Authors & Our journals do not have submission fees. Phomanolides C–F (1–4), four new meroterpenoids, were isolated from a Phoma sp., together with the known phomanolides A (5) and B (6); their structures were elucidated primarily by NMR experiments. Moreover, decreased protein expression of Bcl-2 and increased expression of PARP-1 was observed. Hoshinoamide C (1) did not exhibit any cytotoxicity against HeLa or HL60 cells at 10 μM, but inhibited the growth of the parasites responsible for malaria (IC50 0.96 μM) and African sleeping sickness (IC50 2.9 μM). Their structures were elucidated by extensive spectroscopic analysis and X-ray crystallography. Journal of Natural Products, Articles ASAP (Book Review) Publication Date (Web): December 29, 2020. Natural products remain an important source of drug leads covering unique chemical space and providing significant therapeutic value for the control of cancer and infectious diseases resistant to current drugs. Three new diterpenoids, boesenmaxanes A–C (1–3), with an unprecedented core skeleton consisting of an unusual C–C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. (strain MSX63693). Hydroxyapiol (14), containing a hydroxy group in the aromatic core, was identified as the most potent compound. The anti-inflammatory effect was comparable to diclofenac (30 μg/paw). The structures of the new compounds were elucidated by interpreting their spectroscopic data, particularly 1D and 2D NMR. Restrictions on access to cannabis have eased worldwide, leading to a resurgence in interest in the therapeutic potential of cannabis. Some of the compounds were found after one year of fermentation. Cannabis sativa is one such plant that was used medicinally up until the early part of the 20th century. Journal of Pharmacognosy & Natural Products is an open access journal and publishes manuscripts after thorough peer review. 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